The effectiveness and safety of naldemedine in treating opioid-induced constipation among non-cancer adult patients: updated meta-analysis

Naldemedine 0.2 mg is effective for treating OIC in non-cancer patients and is generally well tolerated, with primarily mild-moderate AEs. Further studies should explore long-term safety and comparisons with other PAMORAs.This review was registered in the PROSPERO databases (CRD42023472575).

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Publication Details

Journal
Expert Opinion on Drug Safety
Published
2025-12-25
DOI
https://doi.org/10.1080/14740338.2025.2610488
Primary Topic
Gastrointestinal motility and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

The effectiveness and safety of naldemedine in treating opioid-induced constipation among non-cancer adult patients: updated meta-analysis

Mohammad M. Alnaeem, Khaled H. Suleiman
Expert Opinion on Drug Safety
Gastrointestinal motility and disorders
article

The effectiveness and safety of naldemedine in treating opioid-induced constipation among non-cancer adult patients: updated meta-analysis

Mohammad M. Alnaeem, Khaled H. Suleiman
article en

Abstract

Naldemedine 0.2 mg is effective for treating OIC in non-cancer patients and is generally well tolerated, with primarily mild-moderate AEs. Further studies should explore long-term safety and comparisons with other PAMORAs.This review was registered in the PROSPERO databases (CRD42023472575).

Expert Opinion on Drug Safety
Al-Zaytoonah University of Jordan (JO)
Good health and well-being
Openalex Percentile: Top 27%
Gastrointestinal motility and disorders
DOISourceOpenAlex
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The effectiveness and safety of naldemedine in treating opioid-induced constipation among non-cancer adult patients: updated meta-analysis — Mohammad M. Alnaeem, Khaled H. Suleiman · Expert Opinion on Drug Safety (2025) | TGRS Research Map | TGRS