Enhanced Hi‐C Capture Analysis Revealed Differential Regulatory Architecture for APOE Between Ancestries
Compared to the AF genome, the EU genome has stronger and more chromatin interactions between APOE and other regions, correlating with its increased chromatin accessibility and providing a potential mechanism for the elevated APOE ε4 expression in EU brains. Ancestry-biased chromatin interactions identified through eHiCA can guide functional analyses to understand the ancestry-specific regulatory mechanisms in an effort to delineate the full AD regulatory landscape.
Authors
- Juan I. Young
- Theresa Schuck
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Wanying Xu (ORCID: https://orcid.org/0009-0000-3262-2013)
- Changiz Geula (ORCID: https://orcid.org/0000-0002-9311-3295)
- Katrina Celis
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Jeffery M. M Vance
- William K. Scott (ORCID: https://orcid.org/0000-0001-9336-6404)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Maria C Robayo
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Sandra Weintraub
- Luciana Bertholim Nasciben
- Sofia Moura
- Margaret Pericak‐Vance
- Marla Gearing
- Larry D Adams
- Farid Rajabli
- Fulai Jin
- David A. A. Bennett
Institutions
- Rush University Medical Center (US)
- University of Miami (US)
- Emory University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Dr. John T. Macdonald Foundation (US)
- Institute on Aging (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106814
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00