Peroxiredoxin‐V perturbation in an Alzheimer's disease mouse model

We conclude that perturbation of PrxV levels and mitochondrial dysregulation may contribute to the increased oxidative stress as observed in APP/PS1 brain. Restoring the PrxV levels may mitigate oxidative stress and thus prevent mitochondrial dysregulation and neurodegeneration in AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_106920
Primary Topic
Redox biology and oxidative stress
Type
article
Field-Weighted Citation Impact
0.00
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article

Peroxiredoxin‐V perturbation in an Alzheimer's disease mouse model

Anant Gupta
Alzheimer s & Dementia
Redox biology and oxidative stress
article

Peroxiredoxin‐V perturbation in an Alzheimer's disease mouse model

Anant Gupta
article en

Abstract

We conclude that perturbation of PrxV levels and mitochondrial dysregulation may contribute to the increased oxidative stress as observed in APP/PS1 brain. Restoring the PrxV levels may mitigate oxidative stress and thus prevent mitochondrial dysregulation and neurodegeneration in AD.

Alzheimer s & DementiaVol. 21(S1)
Indian Institute of Science Bangalore (IN)
Openalex Percentile: Top 36%
Redox biology and oxidative stress
DOIOpen Access PDFOpenAlex
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Peroxiredoxin‐V perturbation in an Alzheimer's disease mouse model — Anant Gupta · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS