Sex differences in the association between sleep duration and blood‐based biomarkers of Alzheimer's disease and neurodegeneration: The Framingham Heart Study
Sex significantly modified associations between sleep duration and BBMs. Specifically, only males showed significant positive associations between longer sleep and elevated t-tau, NfL, and GFAP levels. Relative to females, males have heightened inflammatory responses to sleep disturbances, which may partially explain our sex-specific findings with BBMs of neuronal injury and astrogliosis. Although limited by cross-sectional design and self-reported sleep measures, the findings underscore the relevance of sex-specific analyses in sleep and neurodegeneration research. We will next explore non-linear associations as short and long sleep may relate to BBMs level differently. Future longitudinal studies with objective sleep measurements are needed.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Agustı́n Ruiz (ORCID: https://orcid.org/0000-0003-2633-2495)
- Christopher R. Frei (ORCID: https://orcid.org/0000-0002-0692-4787)
- Vanessa M. Young (ORCID: https://orcid.org/0000-0003-4633-5052)
- Jayandra J. Himali
- Crystal Wiedner
- Antonio L Teixeira
- Andrée‐Ann Baril
- Alexa S Beiser
- Matthew P. Pase
Institutions
- Boston University (US)
- Austin College (US)
- The University of Texas at San Antonio Health Science Center (US)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Institute for Neurodegenerative Disorders (US)
- Fundació ACE (ES)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Monash University (AU)
- Université de Montréal (CA)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099558
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00