Linking Hippocampal Atrophy to Emotional Dysregulation and Sleep Disturbances in Neurodegenerative Disease

Hippocampal atrophy in neurodegenerative diseases may be related to increased apathy, aberrant behaviours, and altered sleep patterns. These findings suggest that diminished hippocampal volumes may impair emotional regulation and introduce compensatory sleep quality mechanisms. Future studies on neurodegenerative diseases with neuroimaging should include full measures of apathy and aberrant behaviour, as well as more objective sleep quality measures (polysomnography or wrist actigraphy) to further explore important relationships with brain atrophy.