Sex and Biomarkers in FTD
Females with s-bvFTD exhibited significantly higher NfL and GFAP levels. This sex difference is not explained by differences in cognitive reserve. Given that NfL plateaus as disease progresses, these findings suggest that females with s-bvFTD may present at a more advanced disease stage upon clinical presentation.
Authors
- Ishana Rue (ORCID: https://orcid.org/0000-0002-8954-1078)
- Andrea Arighi (ORCID: https://orcid.org/0000-0003-2865-3970)
- Zac Chatterton (ORCID: https://orcid.org/0000-0002-6683-1400)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Lina Riedl (ORCID: https://orcid.org/0000-0002-0658-5332)
- Janine Diehl‐Schmid (ORCID: https://orcid.org/0000-0002-7745-1382)
- Olivier Piguet (ORCID: https://orcid.org/0000-0002-4305-7897)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Sterre CM. de Boer
- Inge M.W. Verberk
- Sophie Matis
- Daniela Galimberti
- Sven J van der Lee
- Charlotte E. Teunissen
- Chiara Fenoglio
- Ramon Landin‐Romero
Institutions
- Montreal Neurological Institute and Hospital (CA)
- The University of Sydney (AU)
- University of Milan (IT)
- Douglas Mental Health University Institute (CA)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- UNSW Sydney (AU)
- Cooperative Trials Group for Neuro-Oncology (AU)
- Amsterdam Neuroscience (NL)
- Inn-Salzach-Klinikum (DE)
- Amsterdam University Medical Centers (NL)
- McGill University (CA)
- Technical University of Munich (DE)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_100827
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00