Endogenous Glucocorticoids Moderate the Gastric Inflammatory Response to Helicobacter Infection and Protect from Autoimmunity
Endogenous glucocorticoids attenuate gastric inflammation during Helicobacter infection, supporting bacterial persistence while maintaining immune tolerance. These findings suggest that heightened immune responses to Hpylori may trigger autoimmune gastritis development, which can persist after Hpylori clearance and continue to drive gastric cancer risk.
Authors
- Richard J. DiPaolo (ORCID: https://orcid.org/0000-0002-2191-6689)
- Jonathan T. Busada (ORCID: https://orcid.org/0000-0001-5886-9858)
- Sara R. Druffner
- Melody Zhang (ORCID: https://orcid.org/0000-0001-6341-1024)
- Tyler M. Abner
- Richard M. Peek
- Jordan L. Pascoe
- Salik Hussain
- Maeve T. Morris
- Benjamin C. Duncan
- M.Blanca Piazuelo
Institutions
- West Virginia University (US)
- West Virginia University Hospitals (US)
- Saint Louis University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101699
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00