Identification of regulatory networks involved in microglia subset specification
Our findings prioritize two human microglia subsets as being primarily affected by perturbations in AD genes, and identify transcriptional regulatory networks that could be targeted to modulate microglia population structure in a way that will potentially support the maintenance and/or restoration of tissue homeostasis in AD.
Authors
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Emily Lee
- Marta Olah
- Naren Nimmagadda (ORCID: https://orcid.org/0000-0003-1845-9891)
- Jason C. Ngo
- Falak Sher
Institutions
- Columbia University Irving Medical Center (US)
- Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106777
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00