The effect of APOEε4 on the functional gradient of the brain default network in Alzheimer's disease and its relationship with cognitive functions

The APOEε4 gene impacts the functional connectivity gradient of the default network, especially in the right temporal lobe in AD patients. They are more likely than non-carriers to experience functional network gradient derangement, which is linked to cognitive deterioration. This effect may be related to blood AD markers altering the DMN functional gradient affecting DMN resting-state functional connectivity.