Epigenetic age acceleration is faster in Black adults and is associated with plasma amyloid
We observed that epigenetic aging, measured with DunedinPACE, is accelerated in Black relative to White adults, associated with lower Aβ42/Aβ40 levels, and that this association may be stronger in Black adults. An epigenetic clock trained on a representative dataset is needed to provide better generalizability and to accurately determine the association of epigenetic aging with AD biomarkers in Black adults.
Authors
- Colleen Morse
- Wanding Zhou (ORCID: https://orcid.org/0000-0001-9126-1932)
- L. Shaw
- Lauren Massimo
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Rory Boyle (ORCID: https://orcid.org/0000-0003-0787-6892)
- Nadia Dehghani (ORCID: https://orcid.org/0000-0002-0385-7267)
- P. PennMedicine Biobank
- Hao Xu (ORCID: https://orcid.org/0000-0002-2767-3665)
- Katheryn A. Q. Cousins
- Anurag Verma
- Corey T. McMillan
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107267
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00