Multivariate normative Modeling of structural brain regional volumes and CSF‐based proteomics to investigate personalized effects related to Alzheimer's Disease

GAN-based normative modeling technique introduced here is a useful tool to parse heterogeneity at an individual level. The model detects pathology effects in both structural and molecular data, highlighting its potential at personalized deviation detection.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_102126
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Multivariate normative Modeling of structural brain regional volumes and CSF‐based proteomics to investigate personalized effects related to Alzheimer's Disease

Sai Spandana Chintapalli
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Multivariate normative Modeling of structural brain regional volumes and CSF‐based proteomics to investigate personalized effects related to Alzheimer's Disease

Sai Spandana Chintapalli
article en

Abstract

GAN-based normative modeling technique introduced here is a useful tool to parse heterogeneity at an individual level. The model detects pathology effects in both structural and molecular data, highlighting its potential at personalized deviation detection.

Alzheimer s & DementiaVol. 21(S2)
University of Pennsylvania (US)
Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
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Multivariate normative Modeling of structural brain regional volumes and CSF‐based proteomics to investigate personalized effects related to Alzheimer's Disease — Sai Spandana Chintapalli · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS