The combination of all‐trans retinoic acid and Vorinostat protects neurons from oxidative stress via the Nrf2‐ARE pathway
It is evident that ATRA and VOR, alone or in combination, protect neuronal cells from OS via independent pathways. However, both pathways are important to initiate protection and could be useful to reduce OS during early disease pathogenesis and progression.
Authors
- Sharda P. Singh (ORCID: https://orcid.org/0000-0003-4361-4558)
- Adam Baker (ORCID: https://orcid.org/0000-0003-0791-7324)
- Shane Smith (ORCID: https://orcid.org/0000-0002-7205-496X)
- Ashly Hindle
- J. Josh Lawrence
- Chhanda Bose
Institutions
- Texas Tech University (US)
- Lubbock Christian University (US)
- Translational Therapeutics (United States) (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106950
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00