The effects of phosphorylated tau, amyloid‐β, neuroinflammation and cerebral white matter disease on cerebral perfusion: A path analysis study

This study attempts to examine simultaneous direct and indirect causal pathways between Aβ1-40, p-tau181 and age-at-visit on GM perfusion through GFAP and WMH. Our finding of indirect effect of p-tau181 on GM hypoperfusion suggests a causal downstream effect of elevated p-tau181 resulting in reduced GM perfusion through WMH.