Clinical phenotype and neuropathological correlates in autosomal dominantly inherited familial Alzheimer's disease: insights from a UK case series
Phenotypic heterogeneity in ADAD is influenced by causative gene and mutation type. Examining how mutation-specific patterns of amyloid-β peptide deposition relate to variability in CAA and clinical manifestations might inform the development of more personalised treatment approaches for individuals with ADAD mutations.
Authors
- Helen Rice
- Dilek Ocal (ORCID: https://orcid.org/0000-0003-0934-1613)
- Philip SJ. Weston
- Tammaryn Lashley (ORCID: https://orcid.org/0000-0001-7389-0348)
- Clíona Farrell (ORCID: https://orcid.org/0000-0002-0148-9771)
- Frances K. Wiseman (ORCID: https://orcid.org/0000-0001-9323-3548)
- Natalie S. Ryan (ORCID: https://orcid.org/0000-0003-0361-7455)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-5096-7194)
- Moneeb Nasir
- Nanet Willumsen
- Charlotte Burdon
- Nick C Fox
Institutions
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_098875
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00