Sporothrix schenckii Peptidorhamnomannan-Associated Protein 2 (Pap2) Is Involved in Adhesion and Virulence
These findings demonstrate that the SPSK_06559 protein (Pap2) participates in the initial adhesion to host tissues. Induction of a protective response through immune priming with rPap2 suggest that Pap2 is a promising immunogenic antigen. Reduction of lethality upon blocking Pap2 confirms its essential role in pathogenesis, positioning it as a potential target for the development of new therapies and vaccines against sporotrichosis.
Authors
- Uriel Ramírez-Sotelo (ORCID: https://orcid.org/0000-0002-1370-4635)
- Joaquín Omar Chávez-Santiago
- Manuela Gómez-Gaviria (ORCID: https://orcid.org/0009-0006-6836-913X)
- Héctor M. Mora‐Montes (ORCID: https://orcid.org/0000-0001-6973-0595)
- Dario A Baruch-Martínez (ORCID: https://orcid.org/0009-0006-0332-9700)
- Luisa M Contreras-López
- Andréa Regina Baptista
- Iván Martínez-Duncker
Institutions
- Universidad de Guanajuato (MX)
- Universidade Federal Fluminense (BR)
- Universidad Autónoma del Estado de Morelos (MX)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s572598
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Ciencia y Tecnología
- Universidad de Guanajuato