Plasma pTau and GFAP are associated with subjective cognitive decline and memory concerns in the remote, digital Brain Health Registry cohort
The results suggest that remote, unsupervised, digital measures of SCD and subjective memory concern may be useful to help efficiently identify older adults with elevated plasma pTau and GFAP, who are at risk for cognitive decline and impairment due to AD. This approach can be scaled up to facilitate recruitment for clinical trials and AD observational studies, to identify suitable candidates for AD therapeutics, and for screening in clinical care settings.
Authors
- Juliet Fockler
- Miriam T. Ashford (ORCID: https://orcid.org/0000-0003-4045-6435)
- Diana Truran‐Sacrey
- Joseph Eichenbaum (ORCID: https://orcid.org/0000-0003-1841-5936)
- Kaj Blennow
- Rachel L. Nosheny (ORCID: https://orcid.org/0000-0003-4995-8319)
- Erika Cavallone
- Adam Diaz
- Henrik Zetterberg
- Chengshi Jin
- Scott R. Mackin
- Nicholas J. Ashton
- Michael S. W. Weiner
- Melanie J. Miller
Institutions
- San Francisco VA Medical Center (US)
- University of California, San Francisco (US)
- Northern California Institute for Research and Education (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_101115
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00