Deletion of the <i>N</i> ‐ and C‐termini of tau initiates its aggregation and acquires proteopathic properties
Deletion of the acidic N- and C-termini facilitates tau aggregation and acquires proteopathic properties. Tau<sub>151-391</sub> aggregates effectively induce tau aggregation and site-specific hyperphosphorylation in cultured cells and in vivo in mouse brain.
Authors
- F Liu
- Ruozhen Wu
- Nana Jin
- Yunn Chyn Tung
- Jianlan Gu
- Khalid Iqbal
- Xiaochuan Wang
- Allegra Sieh Ho
- Dandan Chu
- Zhihao Hu
Institutions
- Nantong University (CN)
- New York State Office for People With Developmental Disabilities (US)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107182
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00