Acute systemic inflammation effect on cerebrospinal fluid and blood biomarkers of brain inflammation and injury in dementia: a study in acute hip fracture and memory clinic patients‐ the Ascribed programme

Our findings show hip fracture leads to an increase in axonal injury, significantly beyond that observed in patients with stable dementia. This acute injury appears more severe in those with existing dementia. Additionally, NFL levels were correlated with blood CSF barrier permeability which may suggest a link between axonal damage and BBB disruption. Further research is needed to elucidate the underlying mechanisms of this acute brain injury and explore potential therapeutic interventions.