Impaired Brain to Nasal Turbinates Pathway in Aging Amyloid Positive Subjects Using [1‐11C]‐Butanol PET Imaging
The findings suggest that the nasal pathway may serve as a viable route for CSF drainage in humans, with brain amyloid deposition impairing the drainage efficiency. These results provide novel insights into the relationship between brain amyloid pathology and the nasal clearance mechanism, warranting further investigation into the role of peripheral neurovascular pathways as potential biomarkers for AD. Understanding these mechanisms could pave the way for developing innovative interventions aimed at enhancing drainage pathways and mitigating the impact of amyloid burden on neurodegenerative processes.
Authors
- Henry Rusinek (ORCID: https://orcid.org/0000-0001-6035-6314)
- Tracy Butler (ORCID: https://orcid.org/0000-0003-0130-8122)
- Samantha Keil (ORCID: https://orcid.org/0000-0002-7624-7160)
- J. Ivanidze
- Neel H. Mehta (ORCID: https://orcid.org/0000-0002-5144-4635)
- Kewei Chen
- Yi Li (ORCID: https://orcid.org/0000-0003-2984-0436)
- Mony J. de Leon (ORCID: https://orcid.org/0000-0003-4741-406X)
- Roxana O. O Carare
- Liangdong Zhou
- Gloria Chiang
- Xiuyuan Hugh Wang
Institutions
- Cornell University (US)
- Presbyterian Hospital (US)
- University of Southampton (GB)
- Banner Alzheimer’s Institute
- Weill Cornell Medicine (US)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100912
- Primary Topic
- Nasal Surgery and Airway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00