Towards enhanced translational value: preclinical drug activity testing against actively multiplying, nutrient-starved and pellicle biofilm-embedded <i>Mycobacterium abscessus</i>
The varying levels of drug activity observed across the different M. abscessus populations highlight their distinct physiological relevance. As such, the platform-disc-based biofilm model could serve as a valuable asset in preclinical drug activity assays for M. abscessus.
Authors
- Nicole C. Ammerman (ORCID: https://orcid.org/0000-0001-9359-9144)
- Hannelore I. Bax (ORCID: https://orcid.org/0000-0003-0076-5479)
- Michiel L. Bexkens (ORCID: https://orcid.org/0000-0002-2740-7797)
- Saskia E Mudde (ORCID: https://orcid.org/0000-0002-9910-156X)
- Henriëtte M Meliefste
- Jurriaan E. M. de Steenwinkel
- Corné P de Vogel
- Willem J B van Wamel
Institutions
- Erasmus MC (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1093/jac/dkaf468
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00