Cell type‐specific gene expression changes are associated with cerebral amyloid angiopathy and blood‐brain barrier integrity in Alzheimer's disease
We revealed glia-to-pericytes intercellular interactions and pericytic gene regulatory networks that are potentially perturbed by CAA and BBB breakdown. Future directions include analyzing external snRNAseq datasets and performing functional validations.
Authors
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- C Liu
- Michael G. Heckman (ORCID: https://orcid.org/0000-0003-3770-9331)
- Takahisa Kanekiyo (ORCID: https://orcid.org/0000-0001-6751-9374)
- Troy Carnwath (ORCID: https://orcid.org/0000-0003-2703-9047)
- Yuka A. Martens (ORCID: https://orcid.org/0000-0002-5194-4269)
- GuoJun Bu
- Özkan İş (ORCID: https://orcid.org/0000-0003-4070-6756)
- T PATEL
- Kaancan Deniz (ORCID: https://orcid.org/0000-0002-5496-0598)
- Stephanie R. Oatman
- Mariet Allen (ORCID: https://orcid.org/0000-0002-2685-427X)
- Zachary Quicksall (ORCID: https://orcid.org/0000-0002-8791-0925)
- Shu S. Lin
- Minerva M. Carrasquillo
- Wei Tsai
- Melissa E. Murray
- Frederick Q Tutor‐New
- Nilüfer Ertekin‐Taner
- Thuy T. Nguyen
- Xue Wang
- Yu Yamazaki
- Na Zhao
- Evan Udine
Institutions
- University of Iowa (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106658
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00