Dapagliflozin restores odor‐induced functional integration of POC circuit, but not local olfactory neural activation in patients with type 2 diabetes: a 16‐week randomized parallel comparative study

These results suggest that dapagliflozin and liraglutide have unique neuroprotective effects, respectively. Liraglutide may act on the activation of local olfactory-related regions, while dapagliflozin acts on the functional integration of neural circuits. These findings highlight the importance of targeting both metabolic and neural pathways in the management of T2D-related cognitive decline.