Network‐Based Integrative Single‐Nucleus Multi‐Omics Analysis Reveals Cell Type‐Specific Metabolic Rewiring and Potential Drug Targets for Alzheimer's Disease
The findings systematically reveal a circulating metabolite-mediated signaling rewiring network, which may shed light on cellular metabolic heterogeneity and cellular metabolism-based therapeutics for AD and other AD-related dementia if broadly applied.
Authors
- Yunguang Qiu (ORCID: https://orcid.org/0000-0002-5094-0936)
- Feixiong Cheng
Institutions
- Cleveland Clinic (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106203
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00