Capturing Alzheimer's Disease Heterogeneity With Spatially Independent Patterns of Amyloid Accumulation
We found five cortical and four non-cortical independent components of amyloid-PET signal with high consistency between two radiotracers and which related differentially to GM volumes. This method allowed us to quantify several features that could capture heterogeneous disease processes.
Authors
- Mario Tranfa (ORCID: https://orcid.org/0000-0002-4451-4746)
- Lanius
- Prithvi Arunachalam (ORCID: https://orcid.org/0000-0002-0798-6250)
- van der Flier Wm
- P. Payoux
- Gill Farrar (ORCID: https://orcid.org/0000-0002-0726-723X)
- Leonard Pieperhoff (ORCID: https://orcid.org/0009-0003-9003-4588)
- Marta Marquié
- Tiago Gil Oliveira
- Pablo Martínez‐Lage
- Frank Jessen
- Christopher Buckley
- Rik Vandenberghe
- Bernard J Hanseeuw
- Henk Mutsaerts
- Michael Schöll
- Mercè Boada
- Craig Ritchie
- Juan Domingo Gispert
- Giovanni B. Frisoni
- Pieter Jelle Visser
- Alle Meije Wink
- Lyduine E. Collij
- Andrew W. Stephens
Institutions
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Lund University (SE)
- General Electric (Spain) (ES)
- Buckinghamshire Healthcare NHS Trust (GB)
- Universitat Internacional de Catalunya (ES)
- Maastricht University (NL)
- University Hospital of Geneva (CH)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Amsterdam University Medical Centers (NL)
- Fundacion CITA Alzheimer (ES)
- University Hospital Cologne (DE)
- University College London (GB)
- Geneva College (US)
- University of Naples Federico II (IT)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Amsterdam (NL)
- KU Leuven (BE)
- University of Minho (PT)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099751
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00