Esophageal Cancer Cells Exhibit Heterogeneity in DNA Double-Strand Break Repair and G2/M Checkpoint Arrest Associated With Cell Viability After Ionizing Radiation
Esophageal cancer cell lines with lower capability of RAD51 foci formation exhibited defective DDR and G2/M checkpoint arrest associated with higher radiosensitivity. These findings suggest novel possibilities for predicting the efficacy of DNA damage-inducing cancer therapies, such as chemoradiotherapy, based on DDR proficiency, potentially guiding personalized treatment strategies for esophageal cancer.
Authors
- Takehiko Yokobori (ORCID: https://orcid.org/0000-0003-3284-4796)
- Kohei Tateno
- Motohiro Yamauchi (ORCID: https://orcid.org/0000-0001-5423-5284)
- Takumi Takahashi (ORCID: https://orcid.org/0000-0003-0217-1324)
- Yuki Uchihara (ORCID: https://orcid.org/0000-0002-0052-6315)
- Hikaru Okumura
- Atsushi Shibata (ORCID: https://orcid.org/0000-0001-9701-8730)
- Mayu Isono
- Keiji Suzuki
- Ken Okuda
- Shunji Haruna
- Takaaki Ishikawa
- Tamaki Saito
- Ken Shirabe
- Ryota Hayashi
- Hiroshi Saeki
- Ryuta Suzuki
Institutions
- Kyushu University (JP)
- Gunma University (JP)
- Keio University (JP)
- Japan Radioisotope Association (JP)
- Gunma University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.adro.2025.101987
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Japan Agency for Medical Research and Development
- Suntory Foundation for Life Sciences
- Astellas Pharma
- Foundation for Promotion of Cancer Research
- Astellas Foundation for Research on Metabolic Disorders
- Kobayashi Foundation for Cancer Research
- Princess Takamatsu Cancer Research Fund
- Suntory Foundation
- Japan Society for the Promotion of Science