Contribution of genetic and lifestyle factors in resistance‐ and resilience‐related variability in longitudinal pathologic and neurodegeneration trajectory in Dominantly Inherited Alzheimer's Disease

In ADAD, longitudinal trajectories of pathological accumulation varied by resistance, revealing considerable interindividual variability. Despite similar pathological accumulation, longitudinal trajectories of functional neurodegeneration differed by the degree of resilience, with higher resilience linked to slower neurodegeneration and cognitive deterioration. Resistance was primarily associated with genetic mutations and physical activity, while resilience was influenced by modifiable lifestyle factors, including living arrangements and greater openness to experience, highlighting distinct genetic and lifestyle contributions in determining resistance and resilience in ADAD.