Impact of proton vs. photon radiotherapy on overall survival in the management of spinal chondrosarcoma and mortality risk prediction: A nationwide analysis
Gross total resection (GTR) is the most effective treatment for spinal chondrosarcoma. High-dose radiation therapy (BED > 70 Gy) can be combined with surgery to improve survival in advanced cases. Proton therapy offers superior long-term survival compared to photons, and dose-escalated techniques (Stereotactic Radiosurgery [SRS] and Intensity-modulated radiation therapy [IMRT]) show potential in enhancing outcomes.
Authors
- Daniel Lubelski (ORCID: https://orcid.org/0000-0002-9403-9509)
- Joshua Weinberg (ORCID: https://orcid.org/0000-0002-3464-5697)
- Taha Khalilullah (ORCID: https://orcid.org/0000-0002-1257-3987)
- Jawad M. Khalifeh (ORCID: https://orcid.org/0000-0002-5726-6884)
- Chase H. Foster (ORCID: https://orcid.org/0000-0003-2637-2331)
- Nicholas Theodore (ORCID: https://orcid.org/0000-0001-5355-2683)
- Xinlan Yang
- Yuanxuan Xia (ORCID: https://orcid.org/0000-0001-6152-8392)
- Kristin J Redmond
- Tej Azad
- Abdul Karim Ghaith
- A Karim Ahmed
- Anthony Davidson
Institutions
- Johns Hopkins University (US)
- George Washington University (US)
- Johns Hopkins Medicine (US)
- The Ohio State University (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-12-21
- DOI
- https://doi.org/10.1093/noajnl/vdaf240
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00