Associations Between APOE Genotypes and Neuropathological Outcomes in Alzheimer's Disease: Insights from the NACC Dataset
These findings suggest that TDP-43 proteinopathy modifies the genetic risk associated with APOE, attenuating the impact of APOE-ε4 while amplifying the protective role of APOE-ε2. APOE-ɛ2 carriers appear to have a protective effect. The presence of TDP-43 proteinopathy may further modify these associations. Future studies should explore the impact of additional genetic and environmental factors on AD neuropathology burden.
Authors
- Alfred Kongnyu NJAMNSHI (ORCID: https://orcid.org/0000-0003-0052-1511)
- Yannick N. Wadop (ORCID: https://orcid.org/0000-0002-8955-1874)
- Xueqiu Jian (ORCID: https://orcid.org/0000-0002-0313-6494)
- Bernard Fongang (ORCID: https://orcid.org/0000-0002-8161-1553)
- José E Cavazos (ORCID: https://orcid.org/0000-0001-5777-2608)
- Apochi Obed Okwoli (ORCID: https://orcid.org/0000-0002-4144-3137)
- Biniyam Ayele
- Rebecca Bernal
- Jayandra J. Himali
- Alice Nono Djotsa
- The African Initiative on Bioinformatics Online Training in Neurodegenerative Diseases (AI‐BOND)
- Alfred N. Fonteh
- Agustin Ruiz
- Sudha Seshadri
- Margaret E Flanagan
- Crystal Wiedner
- Muralidharan Sargurupremraj
- Nkouonlack Cyrille
Institutions
- Boston University (US)
- University of Southern California (US)
- Huntington Medical Research Institutes (US)
- Michael E. DeBakey VA Medical Center (US)
- Université de Yaoundé I (CM)
- National Forensic Sciences University (IN)
- University of Buea (CM)
- University of Miami (US)
- Université de Bordeaux (FR)
- The University of Texas at San Antonio Health Science Center (US)
- Baylor College of Medicine (US)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Urology San Antonio (US)
- Institute for Neurodegenerative Disorders (US)
- Framingham Heart Study (US)
- Fundació ACE (ES)
- Dr. John T. Macdonald Foundation (US)
- Catholic University of Central Africa (CM)
- Global Brain Health Institute (US)
- Addis Ababa University (ET)
- The University of Texas at San Antonio (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106320
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00