Inflammation rather than anticitrullinated protein antibodies is associated with cardiovascular mortality in RA: insights from rheumatoid arthritis and coronary artery disease cohorts
ACPA prevalence is not increased in patients with CAD without RA. In RA, the association between ACPA positivity and increased (cardiovascular) mortality was primarily explained by CRP. This highlights the impact of chronic inflammation on cardiovascular outcomes in RA.
Authors
- Jan Leipe (ORCID: https://orcid.org/0000-0001-9684-9700)
- Jane Lindschou (ORCID: https://orcid.org/0000-0002-0891-8129)
- Sofia Ajeganova (ORCID: https://orcid.org/0000-0001-9162-9717)
- Christian Gluud (ORCID: https://orcid.org/0000-0002-8861-0799)
- Per Winkel (ORCID: https://orcid.org/0000-0001-8622-5806)
- Emma C. de Moel (ORCID: https://orcid.org/0000-0002-8940-8330)
- René E. M. Toes (ORCID: https://orcid.org/0000-0002-9618-6414)
- T. Huizinga (ORCID: https://orcid.org/0000-0001-7033-7520)
- Diane van der Woude
- Winfried März
- Janus C. Jakobsen
- Graciela E. Delgado
- Annette H.M. van der Helm - Van Mil
- Veerle F.A.M. Derksen
Institutions
- University of Southern Denmark (DK)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- University Hospital Heidelberg (DE)
- Copenhagen University Hospital (DK)
- Karolinska Institutet (SE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1016/j.ard.2025.11.023
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00