Blunted Microglial Reactivity to Lipopolysaccharide in Alzheimer's Disease: A Novel Insight into Neuroimmune Dysfunction
These findings suggest a paradoxical impairment in microglial reactivity to immune challenges in AD, despite the literature showing an elevated baseline neuroinflammation. This novel observation challenges current models of neuroimmune dysfunction in AD and supports the development of therapies aimed at restoring microglial function rather than broadly suppressing inflammation. Future studies with larger cohorts are needed to confirm these results and explore their therapeutic implications.
Authors
- Jessica Lam (ORCID: https://orcid.org/0009-0009-4272-7543)
- Kelly T. Cosgrove (ORCID: https://orcid.org/0000-0002-5560-1183)
- Arsalan Hashemiaghdam (ORCID: https://orcid.org/0000-0003-1976-9701)
- Arash Salardini (ORCID: https://orcid.org/0000-0003-0193-6217)
- Stephen M. Strittmatter (ORCID: https://orcid.org/0000-0001-8188-3092)
- Daniel F. Camacho (ORCID: https://orcid.org/0000-0002-1605-878X)
- Ansel T. Hillmer (ORCID: https://orcid.org/0000-0002-8105-1381)
- Audrey Ruan
- Adam P. Mecca (ORCID: https://orcid.org/0000-0003-1982-5443)
- Kimberly Nelsen
- Ryan S O'Dell
- Christopher H van Dyck
- Kate M Van Dyck
Institutions
- St. Lawrence University (US)
- Tufts University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Yale University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106912
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00