Protective Lifestyle Changes in Family Homozygous for APOE4

Around 2% of the world's population is homozygous for APOE4, making it increasingly rare for three siblings within one family to present with this genetic makeup, two of whom go on to develop early onset Alzheimer's disease. Further medical testing is warranted regarding the current patient's cognitive status and biomarkers for Alzheimer's Disease. This case study could contribute to a greater understanding of protective lifestyle changes that delay Alzheimer's disease, specifically in patients who are homozygous for the APOE4 gene.