The impact of MRI‐based blood‐brain‐barrier water exchange rate on change in white matter hyperintensities and free water over time
Our preliminary results suggest that BBB k<sub>w</sub> is related to change in WMHs over time and FW at baseline. Greater water exchange across the BBB may contribute to a greater susceptibility to white matter damage. The FW results are consistent with our prior studies correlating k<sub>w</sub> and FW. More work is needed to determine the effects of BBB efficiency on downstream cerebrovascular health.
Authors
- Christopher E. Bauer (ORCID: https://orcid.org/0000-0002-9697-4744)
- Xingfeng Shao (ORCID: https://orcid.org/0000-0002-4130-6204)
- Colleen Pappas (ORCID: https://orcid.org/0000-0001-9140-3558)
- Danny JJ Wang
- Brian T Gold
- Valentinos Zachariou
Institutions
- University of Southern California (US)
- University of Kentucky (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099488
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00