Research Trends and Insights Regarding MicroRNAs in Psoriasis: A Comprehensive Analysis

MicroRNAs (miRNAs) have emerged as key regulators in psoriasis, yet the global research landscape has not been systematically mapped from an informatics and translational perspective. We searched the Web of Science Core Collection on April 23, 2024, for English-language articles and reviews using "TS=(psoriasis) AND TS=(miRNA OR miR)". Records and cited references were exported as TXT/BIB. Bibliometric and network analyses were performed with VOSviewer (v1.6.18, Leiden University, Leiden, Netherlands) and the bibliometrix package in R (v4.2.1, R Foundation for Statistical Computing, Vienna, Austria). Co-authorship, co-occurrence, and citation networks were constructed with predefined thresholds; local vs. global citations were distinguished. Protein-protein/miRNA-target interactions were summarized via STRING (version/date aligned with the bibliometric window). We identified 449 publications (393 articles, 56 reviews) from 2003 to 2024, with a 13.8% annual growth and 28.5 citations per document. Thematic mapping recovered basic themes (psoriasis, keratinocytes, inflammation), motor themes (miR-146a-5p, exosomes, GAB1), and emerging terms (STAT3, adalimumab). A STRING-based summary highlighted hubs (STAT3, PTEN, TRAF6) converging on inflammatory and proliferative pathways. Translational tags co-localized "biomarker/monitoring" with core psoriasis/miRNA clusters, and drug tokens (e.g., adalimumab) appeared in emerging/motor zones, indicating a literature focus that is potentially useful for panel scoping and exploratory endpoint selection. Research on miRNAs in psoriasis shows sustained growth and a shift toward translational topics. The evidence map and prioritized miRNA hubs can inform biomarker panel selection, trial design, and clinical decision support in psoriasis.