Different Patterns of Propagation of Tau Tangle Pathology in Typical Alzheimer's Disease Determine Clinical Sub‐Phenotypes

Our results indicate a model in which, although tau progresses hierarchically, its deposition peaks mainly follow specific networks, which drive tau deposition and, consequently, the clinical manifestations of AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_096615
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Different Patterns of Propagation of Tau Tangle Pathology in Typical Alzheimer's Disease Determine Clinical Sub‐Phenotypes

Val J. Lowe, Tharick Ali Pascoal, Belén Pascual, Joseph C. Masdeu et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Different Patterns of Propagation of Tau Tangle Pathology in Typical Alzheimer's Disease Determine Clinical Sub‐Phenotypes

Val J. Lowe, Tharick Ali Pascoal, Belén Pascual, Joseph C. Masdeu, Guilherme Bauer‐Negrini, Emma Patrice Ruppert, Matheus Scarpatto Rodrigues, Bruna Bellaver, Suzanne L. Baker, Firoza Zubeida Lussier, Andréia Silva da Rocha, Markley Silva Oliveira, David Soleimani‐Meigooni, Juan M. Fortea, Hwamee Oh, Pamela C.L. Ferreira, Livia Amaral, Guilherme Povala, Carolina Soares, Rayan Mroué, Marina Scop Madeiros, Brian A. Gordon, Pedro Rosa‐Neto
article en

Abstract

Our results indicate a model in which, although tau progresses hierarchically, its deposition peaks mainly follow specific networks, which drive tau deposition and, consequently, the clinical manifestations of AD.

Alzheimer s & DementiaVol. 21(S3)
Universitat Autònoma de Barcelona (ES), Houston Methodist (US), Lawrence Berkeley National Laboratory (US), University of Pittsburgh (US), University of California, San Francisco (US), Washington University in St. Louis (US), Brown University (US), Hospital de Sant Pau (ES), University Memory and Aging Center (US), Mayo Clinic in Arizona (US), McGill University (CA)
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Openalex Percentile: Top 34%
Dementia and Cognitive Impairment Research
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