Multiomic Insights into Inflammation‐Driven Microglial Dysregulation in AD

Our preliminary findings suggest that viral-induced peripheral inflammation alters microglia state and homeostasis in a 3xTg-AD model. Despite the clearance of systemic inflammation, the transcriptional profile of microglia remains different in infected vs mock-infected mice. The data suggest peripheral inflammatory stress events alter microglial transcriptional profiles and a "reset" to the original baseline profile is not immediate. The implications on neurodegeneration are being explored.