Oral anticoagulation with versus without antiplatelet therapy in patients with stable coronary artery disease and an indication for anticoagulation: a meta-analysis with trial sequential analysis
In patients with stable CAD requiring OAC, OAC monotherapy significantly reduces bleeding and improves net clinical benefit without increasing ischemic risk. These findings support OAC monotherapy, particularly with DOACs, as the preferred long-term strategy, especially in East Asian populations.
Authors
- Hritvik Jain (ORCID: https://orcid.org/0000-0001-5608-4299)
- Giuseppe Andò (ORCID: https://orcid.org/0000-0001-5552-6382)
- Muhammad Umair Younas
- Pierre François Sabouret (ORCID: https://orcid.org/0000-0002-0243-3673)
- Shrouk Ramadan (ORCID: https://orcid.org/0000-0001-6776-883X)
- Yousif Hameed Kurmasha
- Yasar Sattar
- Ahmed Ibrahim
- Ali Saad Al-Shammari
- M Rafiqul Islam
- Khadeeja Ali Hamzah
Institutions
- Ain Shams University (EG)
- University of Baghdad (IQ)
- Gomal University (PK)
- Sorbonne Université (FR)
- Ark Medical Center (US)
- Azienda Ospedaliera Universitaria Policlinico "G. Martino" (IT)
- Shaheed Suhrawardy Medical College (BD)
- University of Kufa (IQ)
- All India Institute of Medical Sciences (IN)
- Alexandria University (EG)
Publication Details
- Journal
- Expert Opinion on Pharmacotherapy
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1080/14656566.2025.2610371
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.16