ERO1A promotes the proliferation, migration and invasion of bladder cancer through ALOX5 mediated activation of JAK-STAT signaling pathway
In conclusion, this study demonstrates that ERO1A could promote the proliferation, migration, and invasion of bladder cancer cells by regulating the ALOX5/JAK/STAT/autophagy signaling axis. ERO1A may serve as a novel molecular marker for the diagnosis and treatment of clinical bladder cancer patients.
Authors
- Zhiwei Zhao
- Hao Deng
- Guanghai Ji
- Jun Ma
- Jian Huang
- Da Chen
Institutions
- Shanghai Public Health Clinical Center (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1186/s12967-025-07613-w
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35