Practice effects in Subjective Cognitive Decline and Biomarker Positivity
Similar to our prior work in MCI and AD, STPE were associated with three biomarkers of AD in the expected direction (i.e., smaller STPE associated with worse biomarker outcomes), especially in those with SCD. Although these findings need to be replicated in a rigorous, prospective study with a larger and more diverse sample, STPE seems to indicate biomarker positivity in SCD participants, which could be used as a safer and more cost-effective variable for enriching clinical trials in AD.
Authors
- Kevin M. Duff (ORCID: https://orcid.org/0000-0002-9336-2400)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Jace B. King (ORCID: https://orcid.org/0000-0002-0206-0475)
- John M. Hoffman
Institutions
- Oregon Health & Science University (US)
- University of Utah (US)
- Huntsman Cancer Institute (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103148
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00