Integrative multi‐omics analysis reveals physiological and genetic drivers of CSF biomarker variability: implications in neurodegeneration studies
We demonstrate that the main source of variability in the CSF is a non-disease related trait traceable to genetic loci and closely related to ventricular volume. Accounting for this physiological variability is essential for accurate interpretation of CSF biomarkers, with broad implications for neurodegeneration research and clinical practice.
Authors
- Jonas Dehairs (ORCID: https://orcid.org/0000-0002-6789-2264)
- Johannes V. Swinnen (ORCID: https://orcid.org/0000-0002-7720-5077)
- Laura Montrreal (ORCID: https://orcid.org/0000-0002-0010-645X)
- Adelina Orellana (ORCID: https://orcid.org/0000-0002-0204-1944)
- Maitée Rosende‐Roca (ORCID: https://orcid.org/0000-0003-1778-8175)
- Asif Imran Emon (ORCID: https://orcid.org/0000-0002-2331-5174)
- Pablo García‐González (ORCID: https://orcid.org/0000-0003-0125-5403)
- Bart Smets (ORCID: https://orcid.org/0000-0001-8480-0782)
- Victoria M. Fernandez
- A. Ballano Ruiz
- María Eugenia Sáez
- Marta Marquié
- Alfredo Cabrera Socorro
- Raquel Puerta
- Itziar de Rojas
- Lluís Tárraga
- Mercè Boada
Institutions
- Janssen (Belgium) (BE)
- The University of Texas at San Antonio Health Science Center (US)
- Instituto de Salud Carlos III (ES)
- Universitat Internacional de Catalunya (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Centro Andaluz de Biología del Desarrollo (ES)
- Institute for Neurodegenerative Disorders (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099623
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00