Recombinant TRIM72/MG53 protein enhances plasma membrane repair and reduces neurotoxicity in models of Alzheimer’s Disease
These results indicate using rhMG53 to enhance plasma membrane repair capacity can compensate for downstream neurotoxicity in AD neurons induced by Aβ. Our future studies will focus on treating AD mouse models with rhMG53 to determine if the protein can enhance spatial learning and memory and other aspects of AD pathology.
Authors
- Hannah R. Bulgart (ORCID: https://orcid.org/0000-0002-9020-5792)
- Loren E. Wold
- Noah Weisleder (ORCID: https://orcid.org/0000-0003-2710-3088)
- Douglas W. Scharre (ORCID: https://orcid.org/0000-0001-8622-3923)
- Gianni N. Giarrano (ORCID: https://orcid.org/0009-0006-9397-1579)
- Miguel A. Lopez (ORCID: https://orcid.org/0000-0002-4089-3419)
Institutions
- University of Kentucky (US)
- The Ohio State University Wexner Medical Center (US)
- The Ohio State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_096157
- Citations
- 1
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.15