Association of the APOEε <i>4</i> allele in Mexican‐mestizo older adults with subjective cognitive decline and mild cognitive impairment
An association between SCD, MCI and APOEε4 was identified in our sample of mestizo-Mexican older adults; of note, no differences were found for APOEε4 allele between the SCD and MCI groups. The risk of portability of APOEe4 was comparable in SCD and MCI, highlighting SCD as a clinical risk prediction entity in the AD continuum. The relevance of SCD should be further studied in the prevention of dementia by improving early detection.
Authors
- Alberto Ortega‐Vázquez (ORCID: https://orcid.org/0000-0003-2803-9444)
- Yaneth Rodríguez‐Agudelo (ORCID: https://orcid.org/0000-0003-0900-684X)
- Nancy Monroy‐Jaramillo (ORCID: https://orcid.org/0000-0003-2611-0972)
- Ramiro Ruiz‐Garcia (ORCID: https://orcid.org/0000-0003-2220-4074)
- Diego Solano‐Mendoza
- Ángela Acosta‐Amaya
- Salvador Sánchez‐Badajos
- Fernanda Infante‐Esquivel
- David J. Dávila‐Ortiz de Montellano
Institutions
- Universidad Autónoma Metropolitana (MX)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_101299
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00