Association Between Decline in Cognitive Processing Speed and CSF Amyloid‐β 42/40 in Cognitively Healthy Older Adults Aged 70, Followed over 5 to 7 Years: Data from the Gothenburg H70 Birth Cohort Study

Our results suggest that a decline in cognitive processing speed is associated with lower CSF Aβ42/40 before a decline in other cognitive domains appears. Additionally, our results indicate that females experience a slower rate of cognitive decline than males, between ages 70 and 76, independent of Aβ42/40.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_105138
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
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article

Association Between Decline in Cognitive Processing Speed and CSF Amyloid‐β 42/40 in Cognitively Healthy Older Adults Aged 70, Followed over 5 to 7 Years: Data from the Gothenburg H70 Birth Cohort Study

I. Skoog, Tobias Skillbäck, Johan Skoog, Anna Dittrich et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Association Between Decline in Cognitive Processing Speed and CSF Amyloid‐β 42/40 in Cognitively Healthy Older Adults Aged 70, Followed over 5 to 7 Years: Data from the Gothenburg H70 Birth Cohort Study

I. Skoog, Tobias Skillbäck, Johan Skoog, Anna Dittrich, Kaj Blennow, Silke Kern, Henrik Zetterberg, Kelly Rombauts
article en

Abstract

Our results suggest that a decline in cognitive processing speed is associated with lower CSF Aβ42/40 before a decline in other cognitive domains appears. Additionally, our results indicate that females experience a slower rate of cognitive decline than males, between ages 70 and 76, independent of Aβ42/40.

Alzheimer s & DementiaVol. 21(S3)
University of Science and Technology of China (CN), University of Wisconsin–Madison (US), Hong Kong Science and Technology Parks Corporation (HK), Sahlgrenska University Hospital (SE), Sorbonne Université (FR), Institut de Myologie (FR), Pitié-Salpêtrière Hospital (FR), Wisconsin Division of Public Health (US), National Hospital for Neurology and Neurosurgery (GB), Institut du Cerveau (FR), University College London (GB), University of Gothenburg (SE)
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Dementia and Cognitive Impairment Research
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Association Between Decline in Cognitive Processing Speed and CSF Amyloid‐β 42/40 in Cognitively Healthy Older Adults Aged 70, Followed over 5 to 7 Years: Data from the Gothenburg H70 Birth Cohort Study — I. Skoog, Tobias Skillbäck, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS