Optical biomarkers for Alzheimer's disease prediction in a heterogenous clinical cohort
Our results demonstrate that Raman spectroscopy can accurately identify AD using CSF from a mixed clinical cohort in which other causes of dementia are prevalent. Although larger cross-sectional studies are required to assess whether accuracy is retained at a population level, establishing the utility of RS in a clinical population is an important first step towards the translation of optical biomarkers for supporting AD diagnosis in the future.
Authors
- George Devitt (ORCID: https://orcid.org/0000-0001-7179-4459)
- Amritpal Mudher (ORCID: https://orcid.org/0000-0002-0880-1107)
- Angus Prosser
- Christopher Kipps (ORCID: https://orcid.org/0000-0002-5205-9712)
- Sofia Michopoulou (ORCID: https://orcid.org/0000-0003-1974-8388)
- Boyd Ghosh (ORCID: https://orcid.org/0000-0001-5887-9220)
- Sumeet Mahajan
Institutions
- University Hospital Southampton NHS Foundation Trust (GB)
- Essex Cardiothoracic Centre (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100770
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00