Synergies between Small RNA and Protein Biomarkers for Early Detection of Cognitive Impairment – results from EPAD
Our findings highlight that combining small RNA and amyloid protein markers significantly outperforms either biomarker type alone, offering a more robust and precise approach to early AD detection. This integrated strategy addresses current gaps in the AT(N) framework, enhancing stratification and enabling more effective interventions. Small nucleolar RNAs and microRNAs emerge as promising candidates for further exploration as part of this synergistic diagnostic model.
Authors
- Jean Manson (ORCID: https://orcid.org/0000-0002-0175-9890)
- Patrick Neubert (ORCID: https://orcid.org/0000-0002-8292-333X)
- Rastislav Horos
- Julia Jehn (ORCID: https://orcid.org/0000-0002-0444-3015)
- Jasmin Skottke
- Kaja Tikk
- Bruno R. Steinkraus (ORCID: https://orcid.org/0000-0003-3757-1993)
- Jessika Ceiler
- Tobias Sikosek (ORCID: https://orcid.org/0000-0001-9929-3525)
- Marco Heuvelman (ORCID: https://orcid.org/0000-0002-4115-4976)
- Jagoda Mika
- Maurice Frank
- C. Biaggi Rudolf
- Josie Butchart
- Jeffrey L. Cummings
- Marta Sanchez‐Delgado
- Alberto Daniel‐Moreno
- Craig Ritchie
- Mustafa Kahraman
Institutions
- University of Nevada, Las Vegas (US)
- University of St Andrews (GB)
- Hummingbird Diagnostics (Germany) (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099297
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00