Task fMRI recognition activation at midlife associated with gender‐influenced chronic stressor exposure in women at risk of Alzheimer's disease

These findings suggest menopausal status may moderate the association between gender-linked stressor exposure and temporal lobe activation during a challenging memory task. Future investigations will examine continuous estrogen measures to elucidate the mechanistic basis of this interaction. This research could advance our understanding of how sex-specific neuroendocrine factors may influence stress-related cognitive vulnerability in women at high AD risks.