Cognitive Reserve as a Predictor of Cognitive Decline, but Not Age of Diagnosis in Patients with Young‐Onset Alzheimer's Disease: An Underexplored Population

In contrast to studies among LOAD, there was no significant correlation between age and CR among YOAD, suggesting that other mechanisms might be more influential than CR parameters in younger individuals. However, similar to LOAD, YOAD patients with higher education and smaller families experienced faster disease progression, implying that diagnoses are frequently made when brain pathology is already severe. These findings highlight the urgent need for early detection tools and cognitive interventions to ease the challenges faced by these young patients.