PET and Blood Biomarkers as Predictors of Short‐Term Progression in MCI and Mild Dementia: Prospective Insights from a Southeast Asian Middle‐Income Country
Tau PET SUVR in Braak stages 3-4 is a robust marker for short-term cognitive and/or functional deterioration. Plasma p-Tau-217 not only serves a diagnosis but also has prognostic capabilities. Plasma GFAP outperforms plasma NfL in predicting short-term progression. Future studies should focus on the value of these biomarkers in long-term progression.
Authors
- Akarin Hiransuthikul (ORCID: https://orcid.org/0000-0003-1906-8171)
- Kittithatch Booncharoen
- Yuttachai Likitjaroen (ORCID: https://orcid.org/0009-0009-7488-325X)
- Sekh Thanprasertsuk (ORCID: https://orcid.org/0000-0002-0267-1372)
- Kammant Phanthumchinda (ORCID: https://orcid.org/0000-0001-6032-3336)
- Poosanu Thanapornsangsuth (ORCID: https://orcid.org/0000-0002-1317-9404)
Institutions
- Thai Red Cross Society (TH)
- Chulalongkorn University (TH)
- Bangkok Hospital (TH)
- King Chulalongkorn Memorial Hospital (TH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100227
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00