Age‐Related Differences in the Association between <scp>REM</scp> Sleep and the Polygenic Risk for Parkinson's Disease
REM sleep is associated with the PRS for PD in early adulthood, 2 to 5 decades before typical symptoms onset. The association changes from positive in younger individuals, presumably free of alpha-synuclein, to negative in late-midlife individuals, possibly because of the progressive presence of alpha-synuclein aggregates or of the repeated increased oxidative metabolism imposed by REM sleep. Our findings may unravel core associations between PD and sleep and may contribute to novel intervention targets to prevent or delay PD. ANN NEUROL 2026;99:922-934.
Authors
- Mikhail Zubkov
- Gilles Vandewalle (ORCID: https://orcid.org/0000-0003-2483-2752)
- F. Collette
- Christine Bastin (ORCID: https://orcid.org/0000-0002-4556-9490)
- Nasrin Mortazavi
- Christian Berthomier (ORCID: https://orcid.org/0000-0002-2300-9476)
- Christian Degueldre (ORCID: https://orcid.org/0000-0002-9058-4390)
- Puneet Talwar (ORCID: https://orcid.org/0000-0001-7631-7926)
- Aurora Gasparello (ORCID: https://orcid.org/0009-0002-9564-1611)
- Pierre A. A. Maquet
- Christophe Phillips
- Vincenzo Muto
- Ekaterina Koshmanova
Institutions
- University of Liège (BE)
- TechnipFMC (France) (FR)
- Centre Hospitalier Universitaire de Liège (BE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1002/ana.78112
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Fonds De La Recherche Scientifique - FNRS
- Fondation pour la Recherche sur Alzheimer
- Walloon excellence in life sciences and biotechnology
- European Regional Development Fund