Altered plasma <i>p</i> ‐tau in presymptomatic and symptomatic neuronal intranuclear inclusion disease
This study elucidated the biomarkers alteration in NIID comprehensively. The changes of p-tau levels, especially p-tau217, provided a new aspect for the demonstration of NIID pathophysiology, and early alteration of p-tau species and GFAP in preNIID further validated their potential value as early biomarkers of NIID. Impressively, p-tau species could not distinguish NIID from AD.
Authors
- Yan Zeng (ORCID: https://orcid.org/0000-0002-7795-2611)
- Bing Tang (ORCID: https://orcid.org/0000-0001-5859-8250)
- Yun Tian (ORCID: https://orcid.org/0000-0002-8456-5513)
- Sizhe Zhang (ORCID: https://orcid.org/0000-0003-4691-9779)
- Bin Jiao
- Lu Shen
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100133
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00