Interaction Between APOE ε4 Status and Age on Medial Temporal Lobe Structures in Hispanic/Latino Older Adults
Our cross-sectional findings suggest that older adults who are APOE ε4 carriers may have better preservation of gray matter volumes in the right entorhinal cortex compared to APOE e4 non-carriers. Additionally, researchers have suggested that genetic ancestry may influence the relationships between APOE ε4 status and cognitive aging among Hispanic/Latino adults. Future investigations could explore genetic ancestry, other genes, and the APOE ε4 allele to develop a deeper understanding of genetic risk and protection for brain structure and AD in Hispanic/Latino adults.
Authors
- Ariana M. Stickel (ORCID: https://orcid.org/0000-0002-6312-2377)
- Rachel Membreno
- C. Menéndez
Institutions
- San Diego State University (US)
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107523
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00